1) SIR ISAAC (1642-1727).-Natural philosopher, _b._ at Woolsthorpe, Lincolnshire, the _s._ of a small landed proprietor, and _ed._ at the Grammar School of Grantham and at Trinity Coll., Camb. By propounding the binomial theorem, the differential calculus, and the integral calculus, he began in 1665 the wonderful series of discoveries in pure