Реферат: The Helicobacter pylori infection diagnosis

Accepted at the scientific conference "Gastric ulcer and carcinoma of the stomach. New sights on Helocobacter pylori", Moscow 21st April 1997.

Discussed at the round table

Attendees academician FI Komarov, academician VV Serov, academician VT Ivashkin, academician AV Kalinin, corresponding member IA Morozov, professor LI Aruin, professor PY Grigoriev, professor AR Zlatkina, professor SI Rapoport, professor GV Tsodikov, professor ON Minushkin, professor LP Miagkova, professor AA Sheptulin, professor VI Pogromov, MD VA Isakov, MD TL Lapina

The development of the given recommendations were necessitated by the following circumstances:

1.The Helicobacter pylori infecrion is one of the most spreadwide human infections nowadays.

2.The Helicobacter pylori bacterium is

· a cause for developing chronic gastritis associated by helicobacter

· the main factor for gastric and peptic ulcer pathogenesis

· the main factor for developing stomach limphoma of low degree malignancy (maltoma)

· carcinoma of the stomach.

3.Extermination (eradication) of Helicobacter pylori in stomach mucousa in infected patients will lead to:

· vanishing inflammatory infiltrate in stomach mucousa;

· considerable reducing frequency of gastric and peptic ulcer recurrences;

· histologic remissing maltoma of the stomach;

· probably, considerably reducing risk for developing of carcinoma of the stomach.

4.The Helicobacter pylori eradication in mucous membrane of the stomach in infected patients - the most difficult problem in the clinical gastroenterology associated with handling comlicated organisational tasks.

5.Nonadequate and/or incorrect treatment of the Helicobacter pylori infection brings to appearing amongst population a large number of bacterium strains resistant to effect of well-known antibiotics.

The Helicobacter pylori infection diagnosis

Primary diagnosis

The Helicobacter pylori infection diagnosis should be conducted by methods revealing directly the bacterium or the products of its activity in the patient's organism. The following methods satisfy above requirements:

1.Bacteriologic: inoculation of biopsy specimen of stomach mucousa to the differential-diagnostic test medium.

2.Morphologic: "gold standard" in Helicobacter pylori diagnosis: bacterium straining in the gistologic specimen of stomach musousa by Gimsa, toluidine blue, Vartin-Starri, Genta:

· citologic - bacterium straining in smears of biopsy specimen of stomach mucouse by Gimsa, Gram.

3.Respiratory: identification of isotopes 14C or 13C in the air breathed out by the patient; isotopes are identified as a result of marked urea segregation in the patient's stomach under the influence of the Helicobacter pylori bacterium urease.

4.Urease: identification of urease activity in biopsy spesimen of stomach mucousa by means of placing it in liqiud or gel medium consisting substrat, buffer and indicator.

While keeping to all requirements to conducting methods and due sterilisation of endoscopic equipment, the Helicobacter pylori infection primary diagnosis is sufficient to start anti-Helicobacter therapy after discovering the bacterium by one of described above method.

Eradication diagnosis

Eradication means total extermination of the bacterium Helicobacter pylori (both vegetative and coccus forms) in the stomach and duodenum.

1.Eradication diagnosis should be conducted in 4-5 weeks after quitting anti-Helicobacter therapy course, or after quitting treatment of concomitant disease by any antibiotics or antisecretory medicines.

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